Determinants of late diagnosis and treatment of children with retinoblastoma. Analytical review of the organizational and methodological department of the Research Institute of Pediatric Oncology and Hematology at N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia

Introduction . Early diagnosis of oncological diseases is one the most important tasks public health, because improves quality medical care for patients and prognosis disease. Despite advances in oncology, pediatric tumors continue to be diagnosed at advanced stages, which may associated with a delayed visit doctor delay due several factors. Many foreign articles are devoted search analysis significant factors untimely diseases, but few similar works Russia. Purpose study – identify late treatment children retinal using example common childhood tumor retinoblastoma (RB). Material methods A retrospective cohort RB Research Institute Pediatric Oncology Hematology N.N. Blokhin National Medical Center Oncology, Ministry Health Russia (Research Hematology) was performed database hospital cancer registry. The group included from first period 2016 2019 receiving Hematology. Time intervals were calculated based on dates symptom RB, initial consultation, date final by an oncologist or ophthalmologist, therapy child RB. days. Results Data 197 (aged 0 15 years) analyzed, corresponded 262 cases number eyes bilateral unilateral Rb. median diagnostic interval localized (groups B) 30 days, locally C, D E) 41 initiation Age (p = 0.0067) patient gender statistically significantly correlated interval. For strabismus, 91 days < 0.0001), when detected during preventive examination, 17 0.0001). event-free survival depended prevalence process (in groups A, B, C) duration doctors’ 0.0394). distance center not significant. Conclusion Predictors our study: gender, age time diagnosis, specific